Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension

Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension

The recruitment and subsequent polarization of inflammatory monocytes/macrophages in the perivascular regions of pulmonary arteries is a key feature of pulmonary hypertension (PH). However, the mechanisms driving macrophage polarization within the adventitial microenvironment during PH progression r...

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Bibliographic Details
Main Authors: Min Li, Suzette Riddle, Sushil Kumar, Joanna Poczobutt, B. Alexandre McKeon, Maria G. Frid, Maureen Ostaff, Julie A. Reisz, Travis Nemkov, Mehdi A. Fini, Aya Laux, Cheng-Jun Hu, Karim C. El Kasmi, Angelo D’Alessandro, R. Dale Brown, Hui Zhang, Kurt R. Stenmark
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
adventitial fibroblast
macrophage
transcriptomic
metabolomics
mitochondria
C-terminal binding protein-C
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.640718/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.640718/full

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