Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from Cryptococcus gattii Independently of T Cells

Pulmonary Iron Limitation Induced by Exogenous Type I IFN Protects Mice from Cryptococcus gattii Independently of T Cells

Cryptococcus neoformans and Cryptococcus gattii cause fatal infection in immunodeficient and immunocompetent individuals. While these fungi are sibling species, C. gattii infects very few AIDS patients, while C. neoformans infection is an AIDS-defining illness, suggesting that the host response to H...

Full description

Bibliographic Details
Main Authors: Michael J. Davis, Shannon Moyer, Elizabeth S. Hoke, Edward Sionov, Katrin D. Mayer-Barber, Dan L. Barber, Hongyi Cai, Lisa Jenkins, Peter J. Walter, Yun C. Chang, Kyung J. Kwon-Chung
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Cryptococcus gattii
Cryptococcus neoformans
HIV
MDA-5
interferons
iron
Online Access:https://doi.org/10.1128/mBio.00799-19

Internet

https://doi.org/10.1128/mBio.00799-19

Similar Items