Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1

Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1

Decreased serum adiponectin levels in type 2 diabetes has been linked to the onset of mitochondrial dysfunction in diabetic complications by impairing AMPK-SIRT1-PGC-1α signaling via impaired adiponectin receptor 1 (AdipoR1) signaling. Here, we aimed to characterize the previously undefined role of...

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Bibliographic Details
Main Authors: Mark E. Pepin, Christoph Koentges, Katharina Pfeil, Johannes Gollmer, Sophia Kersting, Sebastian Wiese, Michael M. Hoffmann, Katja E. Odening, Constantin von zur Mühlen, Philipp Diehl, Peter Stachon, Dennis Wolf, Adam R. Wende, Christoph Bode, Andreas Zirlik, Heiko Bugger
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Endocrinology
Subjects:
mitochondria
adiponectin
adiponectin receptor
diabetes
heart
proteome
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00872/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00872/full

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