BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance

BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance

Activation-induced cytidine deaminase (AID) is required to purge autoreactive immature and transitional-1 (immature/T1) B cells at the first tolerance checkpoint, but how AID selectively removes self-reactive B cells is unclear. We now show that B cell antigen receptor (BCR) and endosomal Toll-like...

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Bibliographic Details
Main Authors: Masayuki Kuraoka, Pilar B. Snowden, Takuya Nojima, Laurent Verkoczy, Barton F. Haynes, Daisuke Kitamura, Garnett Kelsoe
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
B cell tolerance
activation-induced cytidine deaminase
myeloid primary response gene (88)
B cell receptor signaling
Toll-like receptor signaling
intracellular acidification
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301055

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http://www.sciencedirect.com/science/article/pii/S2211124717301055

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