Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

<p>Abstract</p> <p>Backgound</p> <p>No disease modifying treatment currently exists for Huntington's disease (HD), a fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates of the mutated huntingtin protein. Curcumin is a naturall...

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Bibliographic Details
Main Authors: Hickey Miriam A, Zhu Chunni, Medvedeva Vera, Lerner Renata P, Patassini Stefano, Franich Nicholas R, Maiti Panchanan, Frautschy Sally A, Zeitlin Scott, Levine Michael S, Chesselet Marie-Françoise
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Molecular Neurodegeneration
Subjects:
Huntingtin aggregates
Open field
Climbing
Pole task
Rotarod
Grip strength
Striatal mRNA transcripts
Preclinical therapeutic trial
Online Access:http://www.molecularneurodegeneration.com/content/7/1/12

Internet

http://www.molecularneurodegeneration.com/content/7/1/12

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