The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effector of the Hippo pathway, is required for the proper...

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Bibliographic Details
Main Authors: Aleksander D Szymaniak, Rongjuan Mi, Shannon E McCarthy, Adam C Gower, Taylor L Reynolds, Michael Mingueneau, Maria Kukuruzinska, Xaralabos Varelas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
salivary gland
Hippo pathway
YAP
stem cells
epithelial cells
differentiation
Online Access:https://elifesciences.org/articles/23499

Internet

https://elifesciences.org/articles/23499

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