Alpha Particle Emitter Radiolabeled Antibody for Metastatic Cancer: What Can We Learn from Heavy Ion Beam Radiobiology?

Alpha Particle Emitter Radiolabeled Antibody for Metastatic Cancer: What Can We Learn from Heavy Ion Beam Radiobiology?

Alpha-particle emitter labeled monoclonal antibodies are being actively developed for treatment of metastatic cancer due to the high linear energy transfer (LET) and the resulting greater biological efficacy of alpha-emitters. Our knowledge of high LET particle radiobiology derives primarily from ac...

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Bibliographic Details
Main Authors: Hong Song, Srinivasan Senthamizhchelvan, Robert F. Hobbs, George Sgouros
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Antibodies
Subjects:
radiolabeled antibody
heavy ion beam
alpha particle
high LET
radiobiology
DNA repair
Online Access:http://www.mdpi.com/2073-4468/1/2/124

Internet

http://www.mdpi.com/2073-4468/1/2/124

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