MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures

MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures

This study describes the use of in vivo magnetic resonance spectrocopy (MRS) to monitor brain glutamate and lactate levels in a paraoxon (PO) intoxication model. Our results show that the administration of recombinant glutamate-oxaloacetate transaminase (rGOT) in combination with oxaloacetate (OxAc...

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Bibliographic Details
Main Authors: Angela Ruban, Inbal E. Biton, Arik Markovich, David Mirelman
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:International Journal of Molecular Sciences
Subjects:
brain glutamate scavengers
oxaloacetate
hGOT
MRS
lactate
Online Access:http://www.mdpi.com/1422-0067/16/2/3226

Internet

http://www.mdpi.com/1422-0067/16/2/3226

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