Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines

Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines

IntroductionCertain HLA variants are associated with an increased risk of hypersensitivity reactions to specific drugs. Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG) have issued actionable HLA gene – drug interaction guideline...

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Bibliographic Details
Main Authors: Lisanne E. N. Manson, Jesse J. Swen, Henk-Jan Guchelaar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
HLA genes
pharmacogenomics
hypersensitivity
antiepileptic drugs
abacavir
allopurinol
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.567048/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.567048/full

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