Fluorination of Naturally Occurring N6-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity

Fluorination of Naturally Occurring N6-Benzyladenosine Remarkably Increased Its Antiviral Activity and Selectivity

Recently, we demonstrated that the natural cytokinin nucleosides N6-isopentenyladenosine (iPR) and N6-benzyladenosine (BAPR) exert a potent and selective antiviral effect on the replication of human enterovirus 71. In order to further characterize the antiviral profile of this class of compounds, we...

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Bibliographic Details
Main Authors: Vladimir E. Oslovsky, Mikhail S. Drenichev, Liang Sun, Nikolay N. Kurochkin, Vladislav E. Kunetsky, Carmen Mirabelli, Johan Neyts, Pieter Leyssen, Sergey N. Mikhailov
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
fluorinated N6-benzyladenosines
synthesis and antiviral activity
SAR
enterovirus 71
Online Access:https://www.mdpi.com/1420-3049/22/7/1219

Internet

https://www.mdpi.com/1420-3049/22/7/1219

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