EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation

EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation

Abstract Background Low concentrations of tumor necrosis factor-alpha (TNF-α) and its receptor TNFR2 are both reported to promote osteogenic differentiation of osteoblast precursor cells. Moreover, low concentrations of TNF-α up-regulate the expression of EphB4. However, the molecular mechanisms und...

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Bibliographic Details
Main Authors: Yu Zhang, Chengzhe Yang, Shaohua Ge, Limei Wang, Jin Zhang, Pishan Yang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Molecular and Cell Biology
Subjects:
TNF-α
EphB4
Tumor necrosis factor receptor2 (TNFR2)
MAPK cascades
Osteogenesis
Online Access:http://link.springer.com/article/10.1186/s12860-020-00273-2

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http://link.springer.com/article/10.1186/s12860-020-00273-2

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