Membrane Type 1 Matrix Metalloprotease Cleaves Laminin-10 and Promotes Prostate Cancer Cell Migration

Disruption of the extracellular matrix by proteases is crucial for tumor invasion. Laminin-10 (Ln-10) has previously been identified as a substrate for cell migration and cell adhesion, and is present in the basal lamina (BL) of both normal prostate and prostate cancer. Here, we investigate a role...

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Bibliographic Details
Main Authors: Elisabeth L. Bair, Man Ling Chen, Kathy McDaniel, Kiyotoshi Sekiguchi, Anne E. Cress, Raymond B. Nagle, George Timothy Bowden
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800697