Immunogenicity Risk Profile of Nanobodies

Immunogenicity Risk Profile of Nanobodies

Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess unique characteristics, including a minimal size, providing fast pharmacokinetics, high-target specificity, and an affini...

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Bibliographic Details
Main Authors: Chloé Ackaert, Natalia Smiejkowska, Catarina Xavier, Yann G. J. Sterckx, Sofie Denies, Benoit Stijlemans, Yvon Elkrim, Nick Devoogdt, Vicky Caveliers, Tony Lahoutte, Serge Muyldermans, Karine Breckpot, Marleen Keyaerts
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
nanobody
immunogenicity
anti drug antibodies
dendritic cells
T cell—DC interactions
DC activation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.632687/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.632687/full

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