Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system.

Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal β-glucan from the immune system.

Aspergillus fumigatus is the most common cause of invasive mold disease in humans. The mechanisms underlying the adherence of this mold to host cells and macromolecules have remained elusive. Using mutants with different adhesive properties and comparative transcriptomics, we discovered that the gen...

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Bibliographic Details
Main Authors: Fabrice N Gravelat, Anne Beauvais, Hong Liu, Mark J Lee, Brendan D Snarr, Dan Chen, Wenjie Xu, Ilia Kravtsov, Christopher M Q Hoareau, Ghyslaine Vanier, Mirjam Urb, Paolo Campoli, Qusai Al Abdallah, Melanie Lehoux, Josée C Chabot, Marie-Claude Ouimet, Stefanie D Baptista, Jörg H Fritz, William C Nierman, Jean Paul Latgé, Aaron P Mitchell, Scott G Filler, Thierry Fontaine, Donald C Sheppard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3749958?pdf=render

Internet

http://europepmc.org/articles/PMC3749958?pdf=render

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