High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study) [version 2; peer review: 2 approved]

High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study) [version 2; peer review: 2 approved]

Background: Tuberculous meningitis (TBM), the most severe form of tuberculosis (TB), results in death or neurological disability in >50%, despite World Health Organisation recommended therapy. Current TBM regimen dosages are based on data from pulmonary TB alone. Evidence from recent phase II pha...

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Main Authors: Suzaan Marais, Fiona V Cresswell, Raph L. Hamers, Lindsey H.M. te Brake, Ahmad R. Ganiem, Darma Imran, Ananta Bangdiwala, Emily Martyn, John Kasibante, Enock Kagimu, Abdu Musubire, Kartika Maharani, Riwanti Estiasari, Ardiana Kusumaningrum, Nadytia Kusumadjayanti, Vycke Yunivita, Kogieleum Naidoo, Richard Lessells, Yunus Moosa, Elin M. Svensson, Katherine Huppler Hullsiek, Rob E. Aarnoutse, David R. Boulware, Reinout van Crevel, Rovina Ruslami, David B. Meya
Format: Article
Language:English
Published: Wellcome 2020-08-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/4-190/v2

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https://wellcomeopenresearch.org/articles/4-190/v2

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