A novel RIP1/RIP3 dual inhibitor promoted OPC survival and myelination in a rat neonatal white matter injury model with hOPC graft

A novel RIP1/RIP3 dual inhibitor promoted OPC survival and myelination in a rat neonatal white matter injury model with hOPC graft

Abstract Background The dual inhibitors of receptor interacting protein kinase-1 and -3 (RIP1 and RIP3) play an important role in cell death processes and inflammatory responses. White matter injury (WMI), a leading cause of neurodevelopmental disabilities in preterm infants, which is characterized...

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Bibliographic Details
Main Authors: Chu Zhang, Qian Guan, Hao Shi, Lingsheng Cao, Jing Liu, Zixuan Gao, Wenxi Zhu, Yinxiang Yang, Zuo Luan, Ruiqin Yao
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Neonatal ischemia
hOPC graft
ZJU-37
White matter disease
Inflammasome
Online Access:https://doi.org/10.1186/s13287-021-02532-1

Internet

https://doi.org/10.1186/s13287-021-02532-1

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