Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors

Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors

Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor...

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Bibliographic Details
Main Authors: Lori A. Ramkissoon, Worthy Pegram, James Haberberger, Natalie Danziger, Glenn Lesser, Roy Strowd, Sonika Dahiya, Thomas J. Cummings, Wenya Linda Bi, Malak Abedalthagafi, Pratheesh Sathyan, Kimberly McGregor, Prasanth Reddy, Eric Severson, Erik Williams, Douglas Lin, Claire Edgerly, Richard S. P. Huang, Amanda Hemmerich, James Creeden, Charlotte Brown, Jeffrey Venstrom, Priti Hegde, Jeffrey S. Ross, Brian M. Alexander, Julia Elvin, Shakti H. Ramkissoon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
brain tumor
CSF (cerebrospinal fluid)
genomic profiling
metastatic disease
circulating tumor DNA (ctDNA)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.544680/full

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https://www.frontiersin.org/articles/10.3389/fneur.2020.544680/full

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