FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling

FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling

Abstract Background The formation of supernumerary teeth is an excellent model for studying the molecular mechanisms that control stem/progenitor cell homeostasis needed to generate a renewable source of replacement cells and tissues. Although multiple growth factors and transcriptional factors have...

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Main Authors: Jingyi Wu, Ye Tian, Lu Han, Chao Liu, Tianyu Sun, Ling Li, Yanlei Yu, Bikash Lamichhane, Rena N. D’Souza, Sarah E. Millar, Robb Krumlauf, David M. Ornitz, Jian Q. Feng, Ophir Klein, Hu Zhao, Fuming Zhang, Robert J. Linhardt, Xiaofang Wang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Biology
Subjects:
Glycosaminoglycan
Proteoglycan
Fam20B
Kinase
Supernumerary teeth
Tooth renewal
Online Access:http://link.springer.com/article/10.1186/s12915-020-00813-4

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http://link.springer.com/article/10.1186/s12915-020-00813-4

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