Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells

Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells

Abstract Background Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be avoided by lowered permissible exposure levels. In t...

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Bibliographic Details
Main Authors: Rongrong Wu, Johan Högberg, Mikael Adner, Patricia Ramos-Ramírez, Ulla Stenius, Huiyuan Zheng
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Particle and Fibre Toxicology
Subjects:
Respirable crystalline silica particles
NLRP3 inflammasome
S198 pNLRP3
Mitochondrial depolarization
Carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP)
Double strand brakes (DSB)
Online Access:http://link.springer.com/article/10.1186/s12989-020-00370-2

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http://link.springer.com/article/10.1186/s12989-020-00370-2

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