Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis

Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis

Costello syndrome is a “RASopathy” that is characterized by growth retardation, dysmorphic facial appearance, hypertrophic cardiomyopathy and tumor predisposition. >80% of patients with Costello syndrome harbor a heterozygous germline G12S mutation in HRAS. Altered metabolic regulation has been s...

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Bibliographic Details
Main Authors: Daiju Oba, Shin-ichi Inoue, Sachiko Miyagawa-Tomita, Yasumi Nakashima, Tetsuya Niihori, Seiji Yamaguchi, Yoichi Matsubara, Yoko Aoki
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:EBioMedicine
Subjects:
Costello syndrome
Hras G12S
Mitochondrial fatty acid oxidation
Diet-induced obesity
Cancer metabolism
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417304450

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http://www.sciencedirect.com/science/article/pii/S2352396417304450

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