Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.

To combat the threat of antibiotic-resistant Gram-negative bacteria, novel agents that circumvent established resistance mechanisms are urgently needed. Our approach was to focus first on identifying bioactive small molecules followed by chemical lead prioritization and target identification. Within...

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Bibliographic Details
Main Authors: Scott S Walker, Marc Labroli, Ronald E Painter, Judyann Wiltsie, Brad Sherborne, Nicholas Murgolo, Xinwei Sher, Paul Mann, Paul Zuck, Charles G Garlisi, Jing Su, Stacia Kargman, Li Xiao, Giovanna Scapin, Scott Salowe, Kristine Devito, Payal Sheth, Nichole Buist, Christopher M Tan, Todd A Black, Terry Roemer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5507300?pdf=render

Internet

http://europepmc.org/articles/PMC5507300?pdf=render

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