Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon

Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon

The Zika virus (ZIKV) is a member of the <i>Flaviviridae </i>family and an important human pathogen. Most pathogenic viruses encode proteins that interfere with the activation of host innate immune responses. Like other flaviviruses, ZIKV interferes with the expression of interferon (IFN...

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Bibliographic Details
Main Authors: Rickard Lundberg, Krister Melén, Veera Westenius, Miao Jiang, Pamela Österlund, Hira Khan, Olli Vapalahti, Ilkka Julkunen, Laura Kakkola
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Viruses
Subjects:
zika virus
innate immunity
interferon
ikk epsilon
Online Access:https://www.mdpi.com/1999-4915/11/11/1024

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https://www.mdpi.com/1999-4915/11/11/1024

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