CXCR4 and JUNB double-positive disseminated tumor cells are detected frequently in breast cancer patients at primary diagnosis

CXCR4 and JUNB double-positive disseminated tumor cells are detected frequently in breast cancer patients at primary diagnosis

Background: The chemokine receptor CXCR4 and the transcription factor JUNB, expressed on a variety of tumor cells, seem to play an important role in the metastatic process. Since disseminated tumor cells (DTCs) in the bone marrow (BM) have been associated with worse outcomes, we evaluated the expres...

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Main Authors: Galatea Kallergi, Oliver Hoffmann, Ann-Kathrin Bittner, Lina Papadimitriou, Spyridoula D. Katsarou, Nefeli Zacharopoulou, Michalis Zervakis, Stelios Sfakianakis, Christos Stournaras, Vassilis Georgoulias, Rainer Kimmig, Sabine Kasimir-Bauer
Format: Article
Language:English
Published: SAGE Publishing 2020-04-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758835919895754

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https://doi.org/10.1177/1758835919895754

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