EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation

EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation

Abstract Background The echinoderm microtubule-associated protein-like-4 anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified in a subset of non-small cell lung cancer (NSCLC) patients. They responded positively to ALK inhibitors. This study aimed to characterize the mechanisms triggered...

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Bibliographic Details
Main Authors: Ying Li, Yongwen Li, Hongbing Zhang, Ruifeng Shi, Zihe Zhang, Hongyu Liu, Jun Chen
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Pulmonary Medicine
Subjects:
EML4-ALK
JAK2-STAT pathway
Non-small cell lung cancer
Transformation
Online Access:https://doi.org/10.1186/s12890-021-01553-z

Internet

https://doi.org/10.1186/s12890-021-01553-z

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