TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during ge...

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Bibliographic Details
Main Authors: Fernando Gómez-Herreros, Guido Zagnoli-Vieira, Ioanna Ntai, María Isabel Martínez-Macías, Rhona M. Anderson, Andrés Herrero-Ruíz, Keith W. Caldecott
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00307-y

Internet

https://doi.org/10.1038/s41467-017-00307-y

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