Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)

Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)

Abstract Background Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain metastases. However, WBRT has a poor local tumor control and is associated with a decline in neurocognitive function (NCF). Aim of this trial is to assess the efficacy and safety of a new treatment me...

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Bibliographic Details
Main Authors: Anca-Ligia Grosu, Lars Frings, Iryna Bentsalo, Oliver Oehlke, Franziska Brenner, Angelika Bilger, Jamina Tara Fennell, Thomas Rothe, Sabine Schneider-Fuchs, Erika Graf, Claudia Schmoor, Jürgen Beck, Gerhild Becker, Michael Bock, Karl Egger, Horst Urbach, Claas Lahmann, Ilinca Popp
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
Brain metastases
Hippocampus avoidance
Whole brain radiation therapy
Neurocognitive function
Online Access:http://link.springer.com/article/10.1186/s12885-020-07011-z

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http://link.springer.com/article/10.1186/s12885-020-07011-z

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