Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)
Abstract Background Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain metastases. However, WBRT has a poor local tumor control and is associated with a decline in neurocognitive function (NCF). Aim of this trial is to assess the efficacy and safety of a new treatment me...
Main Authors: | Anca-Ligia Grosu, Lars Frings, Iryna Bentsalo, Oliver Oehlke, Franziska Brenner, Angelika Bilger, Jamina Tara Fennell, Thomas Rothe, Sabine Schneider-Fuchs, Erika Graf, Claudia Schmoor, Jürgen Beck, Gerhild Becker, Michael Bock, Karl Egger, Horst Urbach, Claas Lahmann, Ilinca Popp |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-06-01
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Series: | BMC Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12885-020-07011-z |
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