Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity

The ability of all organisms to copy their genetic information via DNA replication is a prerequisite for cell division and a biological imperative of life. In multicellular organisms, however, mutations arising from DNA replication errors in the germline and somatic cells are the basis of genetic di...

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Bibliographic Details
Main Authors: Tony M. Mertz, Victoria Harcy, Steven A. Roberts
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Genes
Subjects:
Online Access:http://www.mdpi.com/2073-4425/8/1/46