Granzyme A Produced by γ9δ2 T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity

Granzyme A Produced by γ9δ2 T Cells Activates ER Stress Responses and ATP Production, and Protects Against Intracellular Mycobacterial Replication Independent of Enzymatic Activity

Mycobacterium tuberculosis (Mtb), the pathological agent that causes tuberculosis (TB) is the number one infectious killer worldwide with one fourth of the world’s population currently infected. Data indicate that γ9δ2 T cells secrete Granzyme A (GzmA) in the extracellular space triggering the infec...

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Bibliographic Details
Main Authors: Valerio Rasi, David C. Wood, Christopher S. Eickhoff, Mei Xia, Nicola Pozzi, Rachel L. Edwards, Michael Walch, Niels Bovenschen, Daniel F. Hoft
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
Granzyme A
Mycobacterium tuberculosis
BCG
ER stress response
ATP production
2D-DIGE
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.712678/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.712678/full

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