Blockade of platelet glycoprotein receptor Ib ameliorates blood-brain barrier disruption following ischemic stroke via Epac pathway

Blockade of platelet glycoprotein receptor Ib ameliorates blood-brain barrier disruption following ischemic stroke via Epac pathway

Glycoprotein (GP) Ib is a platelet membrane receptor complex exposed to vascular injury, proposed as an effective target for stroke therapy. Previously, we have observed that the GPIb antagonist anfibatide (ANF) could mitigate blood-brain barrier (BBB) disruption following cerebral ischemia/reperfus...

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Bibliographic Details
Main Authors: Wei Chu, Xuemei Sun, Xiaoxiao Zhu, Yu chen Zhao, Jingcheng Zhang, Qin Kong, Lanlan Zhou
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Glycoprotein Ib
Anfibatide
Epac
Blood-brain barrier
Cerebral ischemia/reperfusion
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004807

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http://www.sciencedirect.com/science/article/pii/S0753332221004807

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