In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

Abstract Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiology of psychiatric disorders such as schizophrenia. We aimed to esta...

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Bibliographic Details
Main Authors: Yo-Han Joo, Yun-Kwan Kim, In-Gyu Choi, Hyeon-Jin Kim, Young-Don Son, Hang-Keun Kim, Paul Cumming, Jong-Hoon Kim
Format: Article
Language:English
Published: SpringerOpen 2020-10-01
Series:EJNMMI Research
Subjects:
mGluR5
Knockout
NMDA
Glutamate
FDG
PET
Online Access:http://link.springer.com/article/10.1186/s13550-020-00716-z

Internet

http://link.springer.com/article/10.1186/s13550-020-00716-z

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