Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

Astrocyte- and Neuron-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Effect Complement-Mediated Neurotoxicity

We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer’s disease (AD) patients contain high complement levels. To test the hypothesis that circulating EVs from AD patients can induce complement-mediated neurotoxicity involving Membrane Attack Complex (MAC)...

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Bibliographic Details
Main Authors: Carlos J. Nogueras-Ortiz, Vasiliki Mahairaki, Francheska Delgado-Peraza, Debamitra Das, Konstantinos Avgerinos, Erden Eren, Matthew Hentschel, Edward J. Goetzl, Mark P. Mattson, Dimitrios Kapogiannis
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
neurodegeneration
exosomes
astrocytes
complement
membrane attack complex
Online Access:https://www.mdpi.com/2073-4409/9/7/1618

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https://www.mdpi.com/2073-4409/9/7/1618

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