Synthesis and Biological Activities of a 3'-Azido Analogue of Doxorubicin Against Drug-Resistant Cancer Cells

Synthesis and Biological Activities of a 3'-Azido Analogue of Doxorubicin Against Drug-Resistant Cancer Cells

Doxorubicin (DOX), an anthracycline antibiotic, is one of the most active anticancer chemotherapeutic agents. The clinical use of DOX, however, is limited by the dose-dependant P-glycoprotein (P-gp)-mediated resistance. Herein, a 3′-azido analogue of DOX (ADOX) was prepared from daunorubicin (DNR)....

Full description

Bibliographic Details
Main Authors: Fengshan Wang, Wenpeng Zhang, Huanhua Luo, Liyun Qiu, Qingfeng Liu, Duxin Sun, Peng-George Wang, Shuwen Yu, Guisheng Zhang
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:International Journal of Molecular Sciences
Subjects:
anthracycline
Azido
multidrug resistance
ADOX
P-gp
Online Access:http://www.mdpi.com/1422-0067/13/3/3671/

Internet

http://www.mdpi.com/1422-0067/13/3/3671/

Similar Items