LncRNA APCDD1L-AS1 induces icotinib resistance by inhibition of EGFR autophagic degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 axis in lung adenocarcinoma

LncRNA APCDD1L-AS1 induces icotinib resistance by inhibition of EGFR autophagic degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 axis in lung adenocarcinoma

Abstract Background Epidermal growth factor receptor-tyrosinase kinase inhibitor (EGFR-TKI) resistance is the major obstacle in the treatment of lung adenocarcinoma (LUAD) patients harboring EGFR-sensitive mutations. However, the long non-coding RNAs (lncRNAs) related to EGFR-TKIs resistance and the...

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Bibliographic Details
Main Authors: Jie Wu, Chunlei Zheng, Yizhe Wang, Zichang Yang, Ce Li, Wanxia Fang, Yue Jin, Kezuo Hou, Yang Cheng, Jianfei Qi, Xiujuan Qu, Yunpeng Liu, Xiaofang Che, Xuejun Hu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Biomarker Research
Subjects:
LncRNA APCDD1L-AS1
Lung adenocarcinoma
Icotinib-resistance
Autophagy
SIRT5
Online Access:https://doi.org/10.1186/s40364-021-00262-3

Internet

https://doi.org/10.1186/s40364-021-00262-3

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