Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

The Herb Rhinacanthus nasutus (L.) Kurz, which is native to Thailand and Southeast Asia, has become known for its antioxidant properties. Neuronal loss in a number of diseases including Alzheimer’s disease is thought to result, in part, from oxidative stress. Glutamate causes cell death in the mouse...

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Bibliographic Details
Main Authors: Tewin Tencomnao, Christopher A. Brimson, Varaporn Rakkhitawatthana, James M. Brimson, Sirikalaya J. Brimson
Format: Article
Language:English
Published: MDPI AG 2012-04-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
glutamate
amyloid-β
neuron degeneration
oxidative stress
herbal medicine
Online Access:http://www.mdpi.com/1422-0067/13/4/5074/

Internet

http://www.mdpi.com/1422-0067/13/4/5074/

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