Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons

Mitochondrial Protection by Exogenous Otx2 in Mouse Retinal Neurons

OTX2 (orthodenticle homeobox 2) haplodeficiency causes diverse defects in mammalian visual systems ranging from retinal dysfunction to anophthalmia. We find that the retinal dystrophy of Otx2+/GFP heterozygous knockin mice is mainly due to the loss of bipolar cells and consequent deficits in retinal...

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Bibliographic Details
Main Authors: Hyoung-Tai Kim, Soung Jung Kim, Young-In Sohn, Sun-Sook Paik, Romain Caplette, Manuel Simonutti, Kyeong Hwan Moon, Eun Jung Lee, Kwang Wook Min, Mi Jeong Kim, Dong-Gi Lee, Antonio Simeone, Thomas Lamonerie, Takahisa Furukawa, Jong-Soon Choi, Hee-Seok Kweon, Serge Picaud, In-Beom Kim, Minho Shong, Jin Woo Kim
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715011171

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http://www.sciencedirect.com/science/article/pii/S2211124715011171

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