Developing a Reliable Mouse Model for Cancer Therapy-Induced Cardiovascular Toxicity in Cancer Patients and Survivors

Developing a Reliable Mouse Model for Cancer Therapy-Induced Cardiovascular Toxicity in Cancer Patients and Survivors

BackgroundThe high incidence of cardiovascular events in cancer survivors has long been noted, but the mechanistic insights of cardiovascular toxicity of cancer treatments, especially for vessel diseases, remain unclear. It is well known that atherosclerotic plaque formation begins in the area expos...

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Bibliographic Details
Main Authors: Kyung Ae Ko, Yin Wang, Sivareddy Kotla, Yuka Fujii, Hang Thi Vu, Bhanu P. Venkatesulu, Tamlyn N. Thomas, Jan L. Medina, Young Jin Gi, Megumi Hada, Jane Grande-Allen, Zarana S. Patel, Sarah A. Milgrom, Sunil Krishnan, Keigi Fujiwara, Jun-Ichi Abe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Cancer treatment-related cardiovascular toxicity
atherosclerosis
disturbed blood flow
p90RSK
ionizing radiation
Online Access:http://journal.frontiersin.org/article/10.3389/fcvm.2018.00026/full

Internet

http://journal.frontiersin.org/article/10.3389/fcvm.2018.00026/full

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