Host proteostasis modulates influenza evolution

Host proteostasis modulates influenza evolution

Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens. RNA viruses typically have high mutation rates, resulting in frequent production of protein variants with compromised biophysical properties...

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Bibliographic Details
Main Authors: Angela M Phillips, Luna O Gonzalez, Emmanuel E Nekongo, Anna I Ponomarenko, Sean M McHugh, Vincent L Butty, Stuart S Levine, Yu-Shan Lin, Leonid A Mirny, Matthew D Shoulders
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
heat shock response
Hsp90
mutational landscape
selection
heat shock factor 1
Online Access:https://elifesciences.org/articles/28652

Internet

https://elifesciences.org/articles/28652

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