Synthesis of γ-hydroxypropyl P-chirogenic (±)-phosphorus oxide derivatives by regioselective ring-opening of oxaphospholane 2-oxide precursors

Synthesis of γ-hydroxypropyl P-chirogenic (±)-phosphorus oxide derivatives by regioselective ring-opening of oxaphospholane 2-oxide precursors

The synthesis of P-chirogenic (±)-phosphine oxides and phosphinates via selective nucleophilic ring opening of the corresponding oxaphospholanes is described. Two representative substrates: the phosphonate 2-ethoxy-1,2-oxaphospholane 2-oxide and the phosphinate 2-phenyl-1,2-oxaphospholane 2-oxide we...

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Bibliographic Details
Main Authors: Iris Binyamin, Shoval Meidan-Shani, Nissan Ashkenazi
Format: Article
Language:English
Published: Beilstein-Institut 2015-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chirogenic phosphorus
Grignard reagents
oxaphospholanes
phosphinates
phosphine oxides
Online Access:https://doi.org/10.3762/bjoc.11.143

Internet

https://doi.org/10.3762/bjoc.11.143

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