Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity

Prolyl Hydroxylase Domain-2 Inhibition Improves Skeletal Muscle Regeneration in a Male Murine Model of Obesity

Obesity leads to a loss of muscle mass and impaired muscle regeneration. In obese individuals, pathologically elevated levels of prolyl hydroxylase domain enzyme 2 (PHD2) limit skeletal muscle hypoxia-inducible factor-1 alpha and vascular endothelial growth factor (VEGF) expression. Loss of local VE...

Full description

Bibliographic Details
Main Authors: Indranil Sinha, Dharaniya Sakthivel, Benjamin A. Olenchock, Carla R. Kruse, Jeremy Williams, David E. Varon, Jessica D. Smith, Arin L. Madenci, Kristo Nuutila, Amy J. Wagers
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Endocrinology
Subjects:
obesity
hypoxia
prolyl hydroxylase domain enzymes
skeletal muscle regeneration
vascular endothelial growth factor
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00153/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00153/full

Similar Items