Acetaminophen-Induced Rat Hepatotoxicity Based on M1/M2-Macrophage Polarization, in Possible Relation to Damage-Associated Molecular Patterns and Autophagy

Acetaminophen-Induced Rat Hepatotoxicity Based on M1/M2-Macrophage Polarization, in Possible Relation to Damage-Associated Molecular Patterns and Autophagy

Overdose of acetaminophen (APAP), an antipyretic drug, is an important cause of liver injury. However, the mechanism in the rat model remains undetermined. We analyzed APAP-induced hepatotoxicity using rats based on M1/M2-macrophage functions in relation to damage-associated molecular patterns (DAMP...

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Bibliographic Details
Main Authors: Yuka Tsuji, Mizuki Kuramochi, Hossain M. Golbar, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
DAMP
acetaminophen
APAP
autophagy
rat liver
M1-/M2-macrophage polarization
Online Access:https://www.mdpi.com/1422-0067/21/23/8998

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https://www.mdpi.com/1422-0067/21/23/8998

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