On estimating evolutionary probabilities of population variants
Abstract Background The evolutionary probability (EP) of an allele in a DNA or protein sequence predicts evolutionarily permissible (ePerm; EP ≥ 0.05) and forbidden (eForb; EP < 0.05) variants. EP of an allele represents an independent evolutionary expectation of observing an allele in a populati...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-06-01
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Series: | BMC Evolutionary Biology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12862-019-1455-7 |