On estimating evolutionary probabilities of population variants

Abstract Background The evolutionary probability (EP) of an allele in a DNA or protein sequence predicts evolutionarily permissible (ePerm; EP ≥ 0.05) and forbidden (eForb; EP < 0.05) variants. EP of an allele represents an independent evolutionary expectation of observing an allele in a populati...

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Bibliographic Details
Main Authors: Ravi Patel, Sudhir Kumar
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Evolutionary Biology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12862-019-1455-7