Role of the Metal Center in the Modulation of the Aggregation Process of Amyloid Model Systems by Square Planar Complexes Bearing 2-(2′-pyridyl)benzimidazole Ligands

Role of the Metal Center in the Modulation of the Aggregation Process of Amyloid Model Systems by Square Planar Complexes Bearing 2-(2′-pyridyl)benzimidazole Ligands

The effect of analogue Pd(II)-, Pt(II)-, and Au(III) compounds featuring 2-(2′-pyridyl)benzimidazole on the aggregation propensity of amyloid-like peptides derived from Aβ and from the C-terminal domain of nucleophosmin 1 was investigated. Kinetic profiles of aggregation were eval...

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Bibliographic Details
Main Authors: Daniele Florio, Ilaria Iacobucci, Giarita Ferraro, Ahmed M. Mansour, Giancarlo Morelli, Maria Monti, Antonello Merlino, Daniela Marasco
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceuticals
Subjects:
amyloid aggregation
metallodrugs
gold(iii) compounds
platinum(ii) compounds
palladium(ii) compounds
anti-aggregation properties
Online Access:https://www.mdpi.com/1424-8247/12/4/154

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https://www.mdpi.com/1424-8247/12/4/154

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