Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge

Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge

Voltage gated sodium (Nav) channels contribute to axonal damage following demyelination in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). The Nav1.6 isoform has been implicated as a primary contributor in this process. However, the role of Nav1.6 in immun...

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Bibliographic Details
Main Authors: Barakat Alrashdi, Bassel Dawod, Sabine Tacke, Stefanie Kuerten, Patrice D. Côté, Jean S. Marshall
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
inflammation
experimental autoimmune encephalomyelitis
sodium channel
lipopolysaccharide
mast cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.533423/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.533423/full

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