Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

This study aimed to demonstrate the added value of integrating prior in vitro data and knowledge-rich physiologically based pharmacokinetic (PBPK) models with pharmacodynamics (PD) models. Four distinct applications that were developed and tested are presented here. PBPK models were developed for me...

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Bibliographic Details
Main Authors: Manoranjenni eChetty, Rachel eRose, Khaled eAbduljalil, Nikunjkumar ePatel, Gaohua eLu, Theresa eCain, Masoud eJamei, Amin eRostami-Hodjegan
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Pharmacology
Subjects:
PBPK linked PD models
Genotypes and PD
Heart concentration and QTC
Target site concentrations and PD
Formulation effects on PD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00258/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00258/full

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