Hypomethylation of nerve growth factor (NGF) promotes binding of C/EBPα and contributes to inflammatory hyperalgesia in rats

Hypomethylation of nerve growth factor (NGF) promotes binding of C/EBPα and contributes to inflammatory hyperalgesia in rats

Abstract Background Chronic pain usually accompanied by tissue damage and inflammation. However, the pathogenesis of chronic pain remains unclear. Methods We investigated the role of nerve growth factor (NGF) in chronic inflammatory pain induced by complete Freund’s adjuvant (CFA), explored the meth...

Full description

Bibliographic Details
Main Authors: Hongjie Yuan, Shibin Du, Liping Chen, Xiaoqing Xu, Yufeng Wang, Fuhai Ji
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
NGF
C/EBPα
Inflammatory pain
DNA methylation
Epigenetics
Online Access:https://doi.org/10.1186/s12974-020-1711-1

Internet

https://doi.org/10.1186/s12974-020-1711-1

Similar Items