Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53

Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53

During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of HIV-1 membrane curvature to complete particle assembly. siRNA-mediated knoc...

Full description

Bibliographic Details
Main Authors: Kaushik Inamdar, Feng-Ching Tsai, Rayane Dibsy, Aurore de Poret, John Manzi, Peggy Merida, Remi Muller, Pekka Lappalainen, Philippe Roingeard, Johnson Mak, Patricia Bassereau, Cyril Favard, Delphine Muriaux
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
viruses
plasma membrane
single molecule localisation microscopy
Online Access:https://elifesciences.org/articles/67321

Internet

https://elifesciences.org/articles/67321

Similar Items