Gain-of-Function Mutant TP53 R248Q Overexpressed in Epithelial Ovarian Carcinoma Alters AKT-Dependent Regulation of Intercellular Trafficking in Responses to EGFR/MDM2 Inhibitor

Gain-of-Function Mutant TP53 R248Q Overexpressed in Epithelial Ovarian Carcinoma Alters AKT-Dependent Regulation of Intercellular Trafficking in Responses to EGFR/MDM2 Inhibitor

As the most common gene mutation found in cancers, p53 mutations are detected in up to 96% of high-grade serous ovarian carcinoma (HGSOC). Meanwhile, mutant p53 overexpression is known to drive oncogenic phenotypes in cancer patients and to sustain the activation of EGFR signaling. Previously, we ha...

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Bibliographic Details
Main Authors: Zih-Yin Lai, Kai-Yun Tsai, Shing-Jyh Chang, Yung-Jen Chuang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
p53<sup>R248Q</sup> overexpression
epidermal growth factor receptor (EGFR)
AKT
mouse double minute 2 homolog (MDM2)
combination therapy
Online Access:https://www.mdpi.com/1422-0067/22/16/8784

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https://www.mdpi.com/1422-0067/22/16/8784

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