Operon mRNAs are organized into ORF-centric structures that predict translation efficiency

Operon mRNAs are organized into ORF-centric structures that predict translation efficiency

Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold. The signals controlling differential translation are poorly understood. Our...

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Bibliographic Details
Main Authors: David H Burkhardt, Silvi Rouskin, Yan Zhang, Gene-Wei Li, Jonathan S Weissman, Carol A Gross
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
mRNA secondary structure
DMS-seq
translation efficiency
ribosome profiling
codon usage
Online Access:https://elifesciences.org/articles/22037

Internet

https://elifesciences.org/articles/22037

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