Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress

Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress

Phosphorylated histone H2AX (γ-H2AX), a central player in the DNA damage response (DDR), serves as a biomarker of DNA double-strand break repair. Although DNA damage is generally visualized by the formation of γ-H2AX foci in injured nuclei, it is unclear whether the widespread un...

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Bibliographic Details
Main Authors: Eric Moeglin, Dominique Desplancq, Sascha Conic, Mustapha Oulad-Abdelghani, Audrey Stoessel, Manuela Chiper, Marc Vigneron, Pascal Didier, Laszlo Tora, Etienne Weiss
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
histone variant
H2AX phosphorylation
γ-H2AX
pan-nuclear pattern
monoclonal antibody
cancer cells
cell death
replication stress
chemotherapy
H2AFX gene
knock-out
Online Access:http://www.mdpi.com/2072-6694/11/3/355

Internet

http://www.mdpi.com/2072-6694/11/3/355

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